Molecular Pharmacology of Opioid Receptors

Molecular Pharmacology of δ-Opioid Receptors.

Opioids are among the most effective analgesics available and are the first choice in the treatment of acute severe pain. However, partial efficacy, a tendency to produce tolerance, and a host of ill-tolerated side effects make clinically available opioids less effective in the management of chronic pain syndromes. Given that most therapeutic opioids produce their actions via µ-opioid receptors...

Molecular biology of opioid receptors.

Opium and its derivatives are potent analgesics that also have many other pharmacological effects in the nervous system. These agents and the endogenous opioid peptides exert their effects by interacting with high-affinity receptors. Complementary DNAs encoding the delta, kappa and mu opioid receptors have been isolated and characterized. These receptors, which are members of the superfamily of...

Molecular properties of opioid receptors.

Distribution and physiological significance of opioid receptors in the brain Samir F Atweh & Michael J Kuhar 47 Opiates, second messengers and cell response Robert E West & Richard J Miller Electrophysiological analysis of opioid action in the central nervous system Graeme Henderson Electrophysiology of opioid peptides and sensory systems A W Duggan Actions and distributions of opioid peptides ...

International Union of Pharmacology. XII. Classification of opioid receptors.

Molecular Pharmacology of the Incretin Receptors

The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are important regulators of insulin and glucagon secretion as well as lipid metabolism and appetite. These biological functions make their respective receptors (GIPR and GLP-1R) attractive targets in the treatment of both type 2 diabetes mellitus (T2DM) and obesity. The use of these nati...